83 y, male · 117/min · Irregularly irregular
Palpitations and mild breathlessness.
Study hub
Practise interpretation systematically: step-by-step ECG reading, solved cases, lab values in context, antibiotic spectra and clinical calculators.
Read systematically
Regular rhythm: divide 300 by the number of large squares between two R waves.
Irregular rhythm: count QRS complexes on a 10-second strip and multiply by six.
Normal
60–100 / min
Pitfall
Applying the 300-rule to an irregular rhythm.
Case gallery
83 y, male · 117/min · Irregularly irregular
Palpitations and mild breathlessness.
23 y, female · 148/min · Regular
Sudden palpitations, no chest pain.
58 y, female · 69/min · Sinus
Crushing chest pain with nausea.
45 y, male · 161/min · Regular, wide complex
Palpitations with pre-syncope.
50 y, female · 32/min · Regular escape rhythm
Syncope and fatigue.
62 y, male · 78/min · Sinus, widening QRS
Dialysis patient who missed a session.
30 y, female · 165/min · Regular, narrow complex
Young adult, sudden racing heart.
65 y, female · 69/min · Sinus
Routine pre-operative ECG.
51 y, female · 45/min · Regular sinus
Asymptomatic endurance athlete.
Laboratory
↑ Polycythaemia vera, chronic hypoxia, dehydration, testosterone therapy.
↓ Iron deficiency, blood loss, haemolysis, chronic kidney disease, B12 deficiency.
Always pair with MCV: microcytic points to iron, macrocytic to B12, folate or alcohol.
↑ B12 or folate deficiency, alcohol, hypothyroidism, myelodysplasia.
↓ Iron deficiency, thalassaemia, anaemia of chronic disease, lead exposure.
A normal MCV does not exclude mixed deficiency — check ferritin and B12 separately.
↑ Bacterial infection, corticosteroids, stress response, leukaemia.
↓ Viral infection, chemotherapy, sepsis with exhaustion, bone marrow failure.
Neutropenia below 0.5 ×10⁹/L with fever is a medical emergency requiring antibiotics within one hour.
↑ Reactive thrombocytosis after infection, iron deficiency, essential thrombocythaemia.
↓ ITP, sepsis, DIC, heparin-induced thrombocytopenia, liver disease, EDTA clumping.
Below 50 ×10⁹/L avoid invasive procedures; below 20 ×10⁹/L spontaneous bleeding risk rises sharply.
Pharmacology
Green = reliable activity, amber = partial, grey = no relevant activity.
| Class | Gram + | Gram − | Atypical | Anaerobes | Pseudomonas |
|---|---|---|---|---|---|
Penicillins Penicillin G, Amoxicillin | |||||
Mechanism Bind penicillin-binding proteins and block cell wall cross-linking; bactericidal. Penicillin G · Amoxicillin · Amoxicillin/clavulanate · Piperacillin/tazobactam Typical uses
Cautions True IgE-mediated allergy is rare; rash with amoxicillin during EBV infection is not an allergy. | |||||
Cephalosporins Cefazolin, Cefuroxime | |||||
Carbapenems Meropenem, Imipenem/cilastatin | |||||
Macrolides Azithromycin, Clarithromycin | |||||
Fluoroquinolones Ciprofloxacin, Levofloxacin | |||||
Aminoglycosides Gentamicin, Amikacin | |||||
Glycopeptides Vancomycin, Teicoplanin | |||||
Tetracyclines Doxycycline, Minocycline | |||||
Nitroimidazoles Metronidazole, Tinidazole | |||||
Folate antagonists Co-trimoxazole (TMP/SMX) | |||||
Oxazolidinones Linezolid | |||||
Nursing & clinical
42 gtt/min
≈ 125 mL/h on the pump
Eye opening
Verbal response
Motor response
GCS 15 / 15
E4 V5 M6
Mild